Diagnostic Hybrids

Broad Respiratory Virus Recovery Using Mixed Cell Monolayers

Viral Respiratory disease is caused by more than just Influenza and RSV. R-Mix and R-Mix Too will allow you to culture and identify the major respiratory viruses in a single mixed cell vial: Adenovirus, Parainfluenza (Types 1, 2, and 3), and Metapneumovirus in addition to enhanced rapid isolation of Influenza A, B, and RSV.

Rapid Time to Results, Convenient Testing Formats, and Easy to Interpret Results

Designed for modern virology labs, R-Mix, R-Mix Too, and Diagnostic HYBRIDS D^3® respiratory staining kits give you next day, gold standard results. This total package approach decreases turnaround time for Influenza to under 24 hours and all respiratory viruses to 48 hours, compared to up to 14 days with traditional viral cultures.

The Gold Standard

Viral Culture is the Gold Standard of the industry for diagnosing viral respiratory disease. The use of R-Mix (a mixed monolayer of human adenocarcinoma cells and mink lung cells) or R-Mix Too (a mixed monolayer of human adenocarcinoma cells and Madin-Darby Canine kidney cells) improves the sensitivity of culture when compared to other cell types.

Vials

97-0102     Shell Vial (with coverslip)

Cluster Plates

97-2412     24 well/12 fill
97-2418     24 well/18 fill
97-2424     24 well/24 fill
97-4812     48 well/12 fill
97-4818     48 well/18 fill
97-4824     48 well/24 fill

Educational Resources

• A Multiyear History of Cell Culture During Conversion to Totally Tubeless Virology and Effect on Isolation Rates of Viruses
  

  Phyllis McCurdy and James W. Snyder. University of Louisville School of Medicine and Hospital, Louisville, KY. Download File

• Assessment of the R-Mix Shell Vial System and an Antibody Cocktail for Detection of Human Metapneumovirus at a Comprehensive Cancer Center
  

  Marcus Mpwo and Rocco LaSala. Clinical Microbiology, MD Anderson Cancer Center, Houston, TX.

• Comparison of Culture for Cytopathic Effect to Shell Vial and Fluorescent Antibody Stain for Viral Diagnosis
  

  K. Wilkins, H. McIntire, and J. Coleman. Department of Pathology, University of Mississippi Medical Center, Jackson, MS. Download File

• Comparison of D³ Ultra and D³ DFA Respiratory Virus Screening & ID Kits on R-Mix Too Shell Vials for the Detection of Respiratory Viruses
  

  Romina Alcabasa, Jennifer Wehrlin, and Alexandra Valsamakis. Division of Microbiology, Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland.

• Comparison of Diagnostic HYBRIDS' R-Mix Shell Vials to R-Mix Too Shell Vials Using Respiratory Samples
  

  Kim Eskey, Deborah Z. Aird, Alexandra Valsamakis. Division of Microbiology, Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD. Download File

• Comparison of R-Mix and R-Mix Too Shell Vials to Detect and Propagate Respiratory Viruses
  

  Z. Wilkey, J. Langer, C.A. Petti. ARUP Laboratories, Inc., and Departments of Medicine and Pathology, University of Utah School of Medicine, Salt Lake City, UT.

• Comparison of R-Mix Too FreshCells with Conventional Cell Lines for the Rapid Turnaround Time in the Detection of Respiratory Pathogens Using the Diagnostic Hybrids D³ Ultra Respiratory Screening and Identification Reagents
  

  Cherry-Ann Da Costa, MS, MT, Carol Hamilton, Sara T. Beatrice, PhD, William R. Oleszko, PhD, and Maria Paz Carlos, PhD. New York City Department of Health and Mental Hygiene Public Health Laboratory, New York. Download File

• Comparison of the BinaxNow® Influenza A & B Test Kit and R-Mix Too™ in a Clinical Setting
  

  Tracie Rush, MT (ASCP), and Punam Verma, PhD, D(ABMM). Virginia Mason Medical Center, Seattle, WA. Download File

• Evaluation of Diagnostic HYBRIDS' Modified D³ Respiratory Detection Kit in Direct Specimen Testing and R-Mix Too Shell Vial Cultures
  

  Kathy A. Fauntleroy, Richard Henry, Davise H. Larone. Weill Cornell Medical Center/New York Presbyterian Hospital, New York, NY. Download File

• Evaluation of Diagnostic HYBRIDS' New D³ Metapneumovirus Monoclonal Antibody Stain in Direct Specimen Testing and R-Mix Too Shell Vial Cultures
  

  Richard Henry, Kathy A. Fauntleroy Davise H. Larone. Weill Cornell Medical Center/New York Presbyterian Hospital, New York, NY. Download File

• Human Metapneumovirus Detection Using MGB Eclipse RT PCR and Mixed Cell Culture
  

  KL McRae, JA Bocchini, Jr., A Anga and JM Matthews-Greer. Departments of Pediatrics and Pathology, LSUHSC-S, 1501 Kings Highway, Shreveport, LA.

• Impact of Converting from Conventional Tube Cultures to Shell Vials: A Community Hospital Laboratory's Experience
  

  D. Stevenson, J.Hoffman, K.W. Beckman, and E. Matthews. Borgess Medical Center, Kalamazoo, MI. Download File

• Prevalence of Pediatric Respiratory Infections in a Suburban Philadelphia Hospital
  

  Christine Biggs¹, Christina Lim Overmyer², Larisa Gofman², Lisa DeSalvia², Diana Gonzalez², Melanie Feola², Kathryn T. Iacono², Eli Mordechai², Martin E. Adelson². The Chester County Hospital, West Chester, PA, and ²Department of Research and Development, Medical Diagnostic Laboratories, LLC, Hamilton, NJ.

• Rapid Influenza testing: Rapid Cartridges vs. Rapid Culture in a Commercial Laboratory Setting
  

  Georgia Colasante, David G. Beckwith, Laura Godusky. Health Network Laboratories, Allentown, PA. Download File